PANX1

Entrez Summary: The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008].
UniProt Summary: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. {ECO:0000269|PubMed:16908669, ECO:0000269|PubMed:20829356}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leak channel activity
positive regulation of interleukin-1 alpha secretion
wide pore channel activity
regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 alpha production
regulation of interleukin-1 alpha production
gap junction hemi-channel activity
bleb
protein hexamerization
gap junction
response to ATP
positive regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 secretion
regulation of interleukin-1 beta secretion
response to ischemia
positive regulation of interleukin-1 beta production
calcium channel activity
regulation of interleukin-1 secretion
positive regulation of interleukin-1 production
scaffold protein binding
regulation of interleukin-1 beta production
regulation of interleukin-1 production
protease binding
ion channel binding
response to organophosphorus
positive regulation of cytokine secretion
response to purine-containing compound
calcium ion transmembrane transport
actin filament binding
regulation of cytokine secretion
response to nutrient
calcium ion transport
positive regulation of protein secretion
positive regulation of peptide secretion
divalent metal ion transport
divalent inorganic cation transport
signaling receptor binding
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion