PCGF5

Entrez Summary: N/A
UniProt Summary: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). {ECO:0000250|UniProtKB:Q3UK78, ECO:0000269|PubMed:26151332}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifurtimox 1μM R03 exp141	-2.05
CVT-10216 0.1μM R06 exp278	-1.88
Losmapimod 1μM R07 exp376	-1.77
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.74
WNT3A 44ng/ml R08 exp537	1.85

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inactivation of X chromosome by genetic imprinting
X chromosome
histone H2A-K119 monoubiquitination
PRC1 complex
dosage compensation by inactivation of X chromosome
histone H2A monoubiquitination
regulation of gene expression by genetic imprinting
dosage compensation
genetic imprinting
histone H2A ubiquitination
PcG protein complex
histone monoubiquitination
histone ubiquitination
protein monoubiquitination
regulation of gene expression, epigenetic
RNA polymerase II regulatory region sequence-specific DNA binding
histone modification
covalent chromatin modification
centrosome
DNA-binding transcription factor activity
protein ubiquitination
chromatin organization
protein modification by small protein conjugation
nucleolus
protein modification by small protein conjugation or removal
chromosome organization
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process