PDE6H

Gene Information

Official Symbol: PDE6H
Official Name: phosphodiesterase 6H
Aliases and Previous Symbols: N/A
Entrez ID: 5149
UniProt: Q13956
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010].
UniProt Summary: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17330
Expression level (log2 read counts): -4.6

Expression Distribution

Screen	Score
Losmapimod 1μM R07 exp376	1.77
FK-506 30μM R07 exp359	1.91

cGMP binding
3,5-cyclic-GMP phosphodiesterase activity
photoreceptor outer segment membrane
positive regulation of G protein-coupled receptor signaling pathway
positive regulation of epidermal growth factor receptor signaling pathway
enzyme inhibitor activity
positive regulation of ERBB signaling pathway
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
regulation of G protein-coupled receptor signaling pathway
activation of MAPK activity
visual perception
sensory perception of light stimulus
positive regulation of MAP kinase activity
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
positive regulation of kinase activity
positive regulation of transferase activity
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
sensory perception
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
negative regulation of molecular function
positive regulation of protein modification process
nervous system process
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process