PDE9A

Entrez Summary: The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cGMP catabolic process
3,5-cyclic-nucleotide phosphodiesterase activity
cyclic nucleotide catabolic process
3,5-cyclic-GMP phosphodiesterase activity
cGMP metabolic process
cGMP-mediated signaling
positive regulation of cardiac muscle hypertrophy
positive regulation of muscle hypertrophy
purine ribonucleotide catabolic process
ribonucleotide catabolic process
cyclic nucleotide metabolic process
purine nucleotide catabolic process
purine-containing compound catabolic process
regulation of cardiac muscle hypertrophy
regulation of muscle hypertrophy
nucleotide catabolic process
nucleoside phosphate catabolic process
regulation of muscle adaptation
ruffle membrane
sarcolemma
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
perikaryon
cyclic-nucleotide-mediated signaling
carbohydrate derivative catabolic process
regulation of muscle system process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
second-messenger-mediated signaling
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process