PDIA3

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.17
Quercetin 20μM R08 exp517	-2
GSK-J4 1μM R07 exp362	-1.98
Calcipotriol 5μM R08 exp464	-1.83
GSK-J4 1-1.25μM to day4 R07 exp363	-1.73
Olaparib 4μM R08 exp512	2.06
Myriocin 25μM R06 exp293	2.43

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

disulfide oxidoreductase activity
MHC class I peptide loading complex
peptide disulfide oxidoreductase activity
phospholipase C activity
protein folding in endoplasmic reticulum
protein disulfide isomerase activity
cellular response to interleukin-7
response to interleukin-7
positive regulation of extrinsic apoptotic signaling pathway
phagocytic vesicle
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
cell redox homeostasis
antigen processing and presentation of exogenous peptide antigen via MHC class I
recycling endosome membrane
cysteine-type endopeptidase activity
antigen processing and presentation of peptide antigen via MHC class I
melanosome
regulation of extrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
protein folding
response to endoplasmic reticulum stress
endoplasmic reticulum lumen
regulation of apoptotic signaling pathway
focal adhesion
cell surface
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
cellular homeostasis
oxidation-reduction process
cellular response to cytokine stimulus
endoplasmic reticulum
identical protein binding
response to cytokine
proteolysis
RNA binding