PDK1

Gene Information

Official Symbol: PDK1
Official Name: pyruvate dehydrogenase kinase 1
Aliases and Previous Symbols: N/A
Entrez ID: 5163
UniProt: Q15118
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:7499431}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R05 exp241	-2.02
Hypoxia 5%O2 R04 exp191	-1.8
Monensin 0.3μM R08 exp507	-1.79
NMS-873 0.07μM R07 exp380	-1.79
BI-6727 0.001μM R01 exp42	-1.78
VHL-ligand-1 20μM R07 exp421	-1.71

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13843
Expression level (log2 read counts): 5.36

Expression Distribution

BCDHK Adom3
HATPase c

mitochondrial pyruvate dehydrogenase complex
pyruvate dehydrogenase (acetyl-transferring) kinase activity
hypoxia-inducible factor-1alpha signaling pathway
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of acyl-CoA biosynthetic process
regulation of coenzyme metabolic process
regulation of sulfur metabolic process
intrinsic apoptotic signaling pathway in response to oxidative stress
cell death in response to oxidative stress
regulation of cofactor metabolic process
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
regulation of fatty acid metabolic process
regulation of glucose metabolic process
glucose metabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of cellular carbohydrate metabolic process
intrinsic apoptotic signaling pathway
hexose metabolic process
regulation of cellular ketone metabolic process
cellular response to hypoxia
cellular response to decreased oxygen levels
monosaccharide metabolic process
regulation of carbohydrate metabolic process
cellular response to oxygen levels
protein kinase activity
cellular response to oxidative stress
apoptotic signaling pathway
response to hypoxia
response to decreased oxygen levels
mitochondrial matrix
response to oxygen levels
response to oxidative stress
regulation of lipid metabolic process
regulation of cellular amide metabolic process
regulation of small molecule metabolic process
carbohydrate metabolic process
cell population proliferation
nucleolus