PDZD7

Entrez Summary: This gene encodes a ciliary protein homologous to proteins which are mutated in Usher syndrome patients, and mutations and translocations involving this gene have been associated with two types of Usher syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

USH2 complex
stereocilia ankle link
stereocilia ankle link complex
auditory receptor cell stereocilium organization
detection of mechanical stimulus involved in sensory perception of sound
auditory receptor cell morphogenesis
stereocilium tip
auditory receptor cell development
inner ear auditory receptor cell differentiation
inner ear receptor cell stereocilium organization
detection of mechanical stimulus involved in sensory perception
stereocilium
hair cell differentiation
photoreceptor connecting cilium
inner ear receptor cell development
neuroepithelial cell differentiation
detection of mechanical stimulus
columnar/cuboidal epithelial cell development
photoreceptor inner segment
inner ear receptor cell differentiation
mechanoreceptor differentiation
columnar/cuboidal epithelial cell differentiation
inner ear morphogenesis
ear morphogenesis
detection of external stimulus
detection of abiotic stimulus
sensory perception of sound
sensory perception of mechanical stimulus
epithelial cell development
inner ear development
cilium
response to mechanical stimulus
ear development
sensory organ morphogenesis
embryonic organ morphogenesis
epidermal cell differentiation
epidermis development
cell morphogenesis involved in neuron differentiation
embryonic organ development
protein heterodimerization activity