PHPT1
Gene Information
- Official Symbol: PHPT1
- Official Name: phosphohistidine phosphatase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 29085
- UniProt: Q9NRX4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Exhibits phosphohistidine phosphatase activity. {ECO:0000269|PubMed:19836471, ECO:0000269|PubMed:25574816}.
Pfam Domains GO Terms
Pfam Domains
| Ocnus |
GO Terms
| negative regulation of ATP citrate synthase activity |
| peptidyl-histidine dephosphorylation |
| regulation of ATP citrate synthase activity |
| protein histidine phosphatase activity |
| calcium channel inhibitor activity |
| negative regulation of T cell receptor signaling pathway |
| negative regulation of lyase activity |
| negative regulation of antigen receptor-mediated signaling pathway |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| regulation of actin cytoskeleton reorganization |
| regulation of T cell receptor signaling pathway |
| regulation of lyase activity |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| regulation of antigen receptor-mediated signaling pathway |
| positive regulation of insulin secretion |
| positive regulation of peptide hormone secretion |
| ion channel binding |
| positive regulation of hormone secretion |
| regulation of insulin secretion |
| regulation of peptide hormone secretion |
| protein dephosphorylation |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| negative regulation of transferase activity |
| positive regulation of peptide secretion |
| dephosphorylation |
| regulation of actin cytoskeleton organization |
| regulation of actin filament-based process |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of secretion |
| negative regulation of immune system process |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of peptide secretion |
| positive regulation of cell motility |
| regulation of hormone levels |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of locomotion |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| negative regulation of catalytic activity |
| regulation of secretion |
| regulation of cell motility |
| regulation of cellular localization |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| regulation of protein localization |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of signal transduction |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Epigallocatechin gallate 20μM R05 exp230 | -2.4 |
| Vitamin-D3 40μM R08 exp536 | -2.01 |
| UM0011500 5μM R05 exp245 | -1.99 |
| ABT-702 0.1μM R06 exp260 | -1.95 |
| Erlotinib 10μM R05 exp216 | -1.86 |
| Brefeldin A 0.02μM R00 exp8 | -1.71 |
| PFI-3 10μM R03 exp144 | 1.79 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14725
- Expression level (log2 read counts): 4.46
Expression Distribution
PHPT1 Expression in NALM6 Cells: 4.46
