PHYH

Entrez Summary: This gene is a member of the PhyH family and encodes a peroxisomal protein that is involved in the alpha-oxidation of 3-methyl branched fatty acids. Specifically, this protein converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Mutations in this gene have been associated with Refsum disease (RD) and deficient protein activity has been associated with Zellweger syndrome and rhizomelic chondrodysplasia punctata. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end.
UniProt Summary: Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Alda-1 10μM R06 exp262	-2.13
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.71
HMS-I1 1μM R01 exp46	1.77
Dihydrosphingosine 8μM R08 exp476	1.81
Taxol 0.002μM R01 exp54	2.01
NFN1 0.1μM R01 exp49	2.48
UM131593 0.1μM R01 exp58	2.9

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phytanoyl-CoA dioxygenase activity
2-oxobutyrate catabolic process
2-oxobutyrate metabolic process
methyl-branched fatty acid metabolic process
fatty acid alpha-oxidation
carboxylic acid binding
short-chain fatty acid catabolic process
2-oxoglutarate metabolic process
short-chain fatty acid metabolic process
cofactor binding
L-ascorbic acid binding
ferrous iron binding
peroxisomal matrix
protein localization to peroxisome
protein targeting to peroxisome
establishment of protein localization to peroxisome
peroxisomal transport
fatty acid oxidation
lipid oxidation
peroxisome organization
fatty acid catabolic process
dicarboxylic acid metabolic process
peroxisome
monocarboxylic acid catabolic process
isoprenoid metabolic process
cellular lipid catabolic process
lipid modification
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
fatty acid metabolic process
protein targeting
establishment of protein localization to organelle
small molecule catabolic process
cofactor metabolic process
monocarboxylic acid metabolic process
protein localization to organelle
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process