PITPNB

Entrez Summary: N/A
UniProt Summary: Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 1 to 2μM on day4 R04 exp164	-4.67
Fluvastatin 2.2μM R06 exp282	-3.06
Cerivastatin 0.15μM R05 exp226	-2.87
L-74142 5μM R03 exp131	-2.12
IWR1 50μM R08 exp495	-2.04
5-Fluorouracil 20μM R00 exp2	-1.85
Cannabidiol 20μM R08 exp466	-1.84
TRAIL 50ng/ml R00 exp36	-1.77
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.81
Nicotine 3000μM R08 exp510	2.26
Clomiphene 4.4μM R02 exp68	4.38
Vemurafenib 6.6μM R02 exp89	6.63
Vemurafenib 6.6μM R08 exp434	8

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylcholine transporter activity
phosphatidylinositol transfer activity
phosphatidylcholine binding
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
phosphatidylinositol binding
phospholipid transport
organophosphate ester transport
nucleus organization
lipid transport
lipid localization
Golgi vesicle transport
organic anion transport
anion transport
Golgi membrane
endoplasmic reticulum membrane
lipid metabolic process
ion transport
vesicle-mediated transport