PLAC8
Gene Information
- Official Symbol: PLAC8
- Official Name: placenta associated 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 51316
- UniProt: Q9NZF1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PLAC8 |
GO Terms
| negative regulation of multicellular organism growth |
| brown fat cell differentiation |
| response to cold |
| regulation of multicellular organism growth |
| azurophil granule lumen |
| positive regulation of cold-induced thermogenesis |
| negative regulation of developmental growth |
| fat cell differentiation |
| regulation of cold-induced thermogenesis |
| response to temperature stimulus |
| negative regulation of growth |
| regulation of developmental growth |
| defense response to bacterium |
| chromatin binding |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of growth |
| response to bacterium |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| leukocyte activation |
| negative regulation of developmental process |
| defense response to other organism |
| negative regulation of cell death |
| secretion by cell |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of cell death |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53 | -2.01 |
| BI-6727 0.001μM R01 exp42 | -1.91 |
| Demecolcine 0.03μM R05 exp228 | -1.74 |
| YM155 0.001μM R08 exp432 | 1.98 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17055
- Expression level (log2 read counts): 3.27
Expression Distribution
PLAC8 Expression in NALM6 Cells: 3.27
