PLCB3

Entrez Summary: N/A
UniProt Summary: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BH1 1μM R04 exp169	-1.83
Resminostat 0.5μM R07 exp393	1.83

phospholipase C activity
inositol trisphosphate biosynthetic process
postsynaptic cytosol
inositol trisphosphate metabolic process
phosphatidylinositol phospholipase C activity
inositol phosphate biosynthetic process
Wnt signaling pathway, calcium modulating pathway
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
inositol phosphate metabolic process
polyol biosynthetic process
calcium ion transmembrane import into cytosol
phosphatidylinositol-mediated signaling
calcium ion transport into cytosol
inositol lipid-mediated signaling
cytosolic calcium ion transport
regulation of systemic arterial blood pressure
polyol metabolic process
alcohol biosynthetic process
regulation of sequestering of calcium ion
non-canonical Wnt signaling pathway
regulation of blood pressure
organic hydroxy compound biosynthetic process
calcium ion transmembrane transport
calmodulin binding
calcium ion transport
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
lipid catabolic process
divalent inorganic cation transport
cadherin binding
alcohol metabolic process
regulation of cytosolic calcium ion concentration
Wnt signaling pathway
cell-cell signaling by wnt
blood circulation
circulatory system process
cell surface receptor signaling pathway involved in cell-cell signaling
cellular calcium ion homeostasis
calcium ion homeostasis