PLCB4

Entrez Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phospholipase C activity
inositol trisphosphate biosynthetic process
parallel fiber to Purkinje cell synapse
inositol trisphosphate metabolic process
phosphatidylinositol phospholipase C activity
inositol phosphate biosynthetic process
smooth endoplasmic reticulum
inositol phosphate metabolic process
polyol biosynthetic process
polyol metabolic process
alcohol biosynthetic process
organic hydroxy compound biosynthetic process
postsynaptic density
lipid catabolic process
alcohol metabolic process
glutamatergic synapse
dendrite
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
organic hydroxy compound metabolic process
organophosphate biosynthetic process
small molecule biosynthetic process
calcium ion binding
organophosphate metabolic process
lipid metabolic process
G protein-coupled receptor signaling pathway
intracellular signal transduction
small molecule metabolic process
organic substance catabolic process