PNRC2
Gene Information
- Official Symbol: PNRC2
- Official Name: proline rich nuclear receptor coactivator 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 55629
- UniProt: Q9NPJ4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). {ECO:0000250|UniProtKB:Q9CR73, ECO:0000269|PubMed:11574675, ECO:0000269|PubMed:19150429, ECO:0000269|PubMed:25775514}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4856
- Expression level (log2 read counts): 7.29
PNRC2 Expression in NALM6 Cells: 7.29
