PPP1CB

Gene Information

Official Symbol: PPP1CB
Official Name: protein phosphatase 1 catalytic subunit beta
Aliases and Previous Symbols: N/A
Entrez ID: 5500
UniProt: P62140
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
UniProt Summary: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R01 exp48	-2.3
AICAR 240μM R05 exp211	-2.11
2-Methoxyestradiol 0.2μM R01 exp40	-2.09
Citral 75μM R06 exp275	-1.92
LLY-283 2.6μM R06 exp290	-1.88
Aphidicolin 0.04μM R06 exp263	-1.86
Genistein 15μM R07 exp360	-1.85
Nutlin-3A 1.6μM R06 exp294	-1.82
Sulforaphane 9μM R08 exp526 no dilution day6	2.01

Global Fraction of Cell Lines Where Essential: 37/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	2/28
blood	2/28
bone	2/25
breast	2/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/15
kidney	1/21
liver	1/20
lung	3/75
lymphocyte	1/14
ovary	0/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	1/7
thyroid	1/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 844
Expression level (log2 read counts): 7.11

Expression Distribution

myosin-light-chain-phosphatase activity
myosin phosphatase activity
regulation of glycogen catabolic process
glycogen granule
PTW/PP1 phosphatase complex
regulation of cellular carbohydrate catabolic process
protein phosphatase type 1 complex
entrainment of circadian clock by photoperiod
photoperiodism
entrainment of circadian clock
regulation of glucan biosynthetic process
regulation of glycogen biosynthetic process
regulation of glycogen metabolic process
regulation of polysaccharide biosynthetic process
regulation of polysaccharide metabolic process
phosphatase activity
glycogen metabolic process
glucan metabolic process
cellular glucan metabolic process
circadian regulation of gene expression
energy reserve metabolic process
protein serine/threonine phosphatase activity
cellular polysaccharide metabolic process
polysaccharide metabolic process
regulation of carbohydrate catabolic process
regulation of carbohydrate biosynthetic process
nuclear chromosome, telomeric region
regulation of glucose metabolic process
regulation of circadian rhythm
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
regulation of cellular carbohydrate metabolic process
circadian rhythm
regulation of generation of precursor metabolites and energy
cellular carbohydrate metabolic process
regulation of carbohydrate metabolic process
protein dephosphorylation
energy derivation by oxidation of organic compounds
mitotic cell cycle phase transition
rhythmic process