PRDX5
Gene Information
- Official Symbol: PRDX5
- Official Name: peroxiredoxin 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 25824
- UniProt: P30044
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Redoxin |
| AhpC-TSA |
GO Terms
| negative regulation of transcription by RNA polymerase III |
| RNA polymerase III regulatory region DNA binding |
| thioredoxin peroxidase activity |
| regulation of transcription by RNA polymerase III |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| hydrogen peroxide catabolic process |
| peroxidase activity |
| hydrogen peroxide metabolic process |
| peroxisomal matrix |
| antibiotic catabolic process |
| cofactor catabolic process |
| cell redox homeostasis |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular oxidant detoxification |
| negative regulation of cysteine-type endopeptidase activity |
| cellular detoxification |
| antibiotic metabolic process |
| peroxisome |
| reactive oxygen species metabolic process |
| detoxification |
| cellular response to reactive oxygen species |
| drug catabolic process |
| protein dimerization activity |
| response to reactive oxygen species |
| cellular response to toxic substance |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to oxidative stress |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| cytoplasmic vesicle |
| negative regulation of peptidase activity |
| negative regulation of proteolysis |
| mitochondrial matrix |
| response to oxidative stress |
| regulation of endopeptidase activity |
| cofactor metabolic process |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| inflammatory response |
| drug metabolic process |
| response to toxic substance |
| intracellular membrane-bounded organelle |
| perinuclear region of cytoplasm |
| regulation of proteolysis |
| negative regulation of catalytic activity |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| apoptotic process |
| oxidation-reduction process |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| cell death |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| regulation of hydrolase activity |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| extracellular space |
| homeostatic process |
| regulation of cell death |
| cellular response to stress |
| negative regulation of gene expression |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dexamethasone 0.006 to 0.015μM on day4 R07 exp352 | 2.01 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.482 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15488
- Expression level (log2 read counts): 4.15
Expression Distribution
PRDX5 Expression in NALM6 Cells: 4.15
