PROSER1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
AICAR 240μM R03 exp116	-2.39
Chloroquine 32μM R08 exp470	-2.33
A-769662 20μM R07 exp331	-2.28
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.07
MLN-4924 0.2μM R00 exp21	-1.99
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.98
SB203580 25μM R03 exp149	-1.86
Cyclosporin-A 3μM R07 exp348	-1.85
GSK-J4 1μM R07 exp362	-1.84
Nicotinamide 2000μM R01 exp50	-1.83
Tubacin 1.6μM R07 exp416	-1.81
INK128 0.2μM R02 exp70	-1.77
Ibrutinib 10μM R08 exp442	-1.76
GSK461364A 0.005μM R03 exp125	-1.74
MS023 2μM R03 exp134	-1.73
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.72
Rapamycin 10μM R00 exp30	-1.7
LY2090314 0.003μM R08 exp500 no dilution day6	1.92
THZ1 0.06μM R08 exp531	2.09

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution