PSD

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.9
Ribavirin 10μM R01 exp52	1.77
Vinblastine 0.002μM R01 exp60	2.03

PH
Sec7

extrinsic component of postsynaptic endosome membrane
postsynaptic density, intracellular component
ARF guanyl-nucleotide exchange factor activity
regulation of ARF protein signal transduction
cleavage furrow
ruffle membrane
phospholipid binding
dendritic spine
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
neuron projection development
neuron development
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
generation of neurons
neurogenesis
cell development
regulation of intracellular signal transduction