PTBP3

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.87
Aphidicolin 0.4μM R08 exp440	1.87
Nutlin-3A 1.6μM R06 exp294	1.87
Lead acetate 2000μM R08 exp498 no dilution day6	1.89
BI-D1870 3.15μM R02 exp66	1.94
I-BRD9 4μM R07 exp365	2
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.04
Pyridostatin 4μM R05 exp240	2.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

erythrocyte maturation
negative regulation of RNA splicing
erythrocyte development
myeloid cell development
erythrocyte differentiation
erythrocyte homeostasis
myeloid cell homeostasis
anatomical structure maturation
regulation of RNA splicing
cell maturation
homeostasis of number of cells
myeloid cell differentiation
developmental maturation
RNA splicing
mRNA processing
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
mRNA metabolic process
RNA processing
negative regulation of RNA metabolic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
homeostatic process
cell development
RNA metabolic process
negative regulation of gene expression
regulation of cell differentiation
gene expression