PTPRD

Gene Information

Official Symbol: PTPRD
Official Name: protein tyrosine phosphatase receptor type D
Aliases and Previous Symbols: N/A
Entrez ID: 5789
UniProt: P23468
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010].
UniProt Summary: Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. {ECO:0000250|UniProtKB:Q64487}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12881
Expression level (log2 read counts): -1.01

Expression Distribution

Screen	Score
Ribavirin 10μM R01 exp52	-1.93
Vinorelbine 0.001μM R05 exp249	-1.71
Aphidicolin 0.04μM R06 exp263	2.2

Y phosphatase
fn3
I-set

transmembrane receptor protein tyrosine phosphatase signaling pathway
trans-synaptic signaling by trans-synaptic complex
presynaptic membrane assembly
regulation of postsynaptic density assembly
presynaptic membrane organization
regulation of postsynapse assembly
regulation of postsynaptic specialization assembly
regulation of excitatory synapse assembly
regulation of postsynaptic density organization
transmembrane receptor protein tyrosine phosphatase activity
presynapse assembly
presynapse organization
synaptic membrane adhesion
regulation of presynapse assembly
regulation of presynapse organization
membrane assembly
positive regulation of dendrite morphogenesis
membrane biogenesis
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion molecule binding
positive regulation of synapse assembly
positive regulation of dendrite development
regulation of dendrite morphogenesis
synapse assembly
regulation of postsynapse organization
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
regulation of synapse assembly
regulation of dendrite development
positive regulation of cell morphogenesis involved in differentiation
protein dephosphorylation
regulation of synapse organization
regulation of organelle assembly
regulation of synapse structure or activity
cell-cell adhesion via plasma-membrane adhesion molecules
synapse organization
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
dephosphorylation
signaling receptor binding