PYGM
Gene Information
- Official Symbol: PYGM
- Official Name: glycogen phosphorylase, muscle associated
- Aliases and Previous Symbols: N/A
- Entrez ID: 5837
- UniProt: P11217
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009].
- UniProt Summary: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2613
- Expression level (log2 read counts): 2.42
PYGM Expression in NALM6 Cells: 2.42
