RAB5C

Entrez Summary: N/A
UniProt Summary: Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 0.2μM R00 exp21	-3.66
Deferoxamine 11μM R07 exp350	-2.4
Golgicide-A 4μM R03 exp122	-2.28
TRAIL 50ng/ml R00 exp36	-2
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.85
Chloroquine 32μM R08 exp470	-1.82
Dynasore 7μM R08 exp436	-1.82
CoCl2 18μM R07 exp346	-1.73
UM0131023 0.05μM R05 exp248	1.73
NFN1 0.1μM R01 exp49	1.76
BI-6727 0.001μM R01 exp42	1.99
KU-0063794 3.8μM R02 exp71	2.09
Cannabidiol 13μM R08 exp465	2.14
SB203580 25μM R03 exp149	2.25
CCT251545 20μM R07 exp326	2.54

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

plasma membrane to endosome transport
endocytic vesicle
azurophil granule membrane
Rab protein signal transduction
GDP binding
lipid droplet
melanosome
early endosome membrane
regulation of endocytosis
Ras protein signal transduction
early endosome
endosome
lysosomal membrane
small GTPase mediated signal transduction
GTPase activity
GTP binding
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
regulation of vesicle-mediated transport
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
intracellular protein transport
secretion by cell
export from cell
cell activation
immune effector process
secretion
protein transport
intracellular transport