RABEP1

Entrez Summary: N/A
UniProt Summary: Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. {ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rab5-bind
Rabaptin

protein localization to ciliary membrane
protein localization to cilium
endocytic vesicle
Golgi to plasma membrane transport
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
recycling endosome
membrane fusion
early endosome membrane
growth factor activity
protein localization to cell periphery
protein domain specific binding
early endosome
endosome
GTPase activator activity
Golgi vesicle transport
positive regulation of GTPase activity
protein localization to membrane
regulation of GTPase activity
endocytosis
protein-containing complex
import into cell
intracellular membrane-bounded organelle
protein localization to organelle
positive regulation of hydrolase activity
membrane organization
protein homodimerization activity
apoptotic process
programmed cell death
cell death
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of molecular function
nitrogen compound transport