RBM4

Gene Information

Official Symbol: RBM4
Official Name: RNA binding motif protein 4
Aliases and Previous Symbols: N/A
Entrez ID: 5936
UniProt: Q9BWF3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2- containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CR131-b 0.005μM R08 exp474	1.81
Rapamycin 0.001μM R08 exp429	1.85
Clomiphene 4.4μM R02 exp68	1.86
5-Azacytidine 2μM R07 exp330	1.92
Ethanol 0.01 R05 exp234	2.18

Global Fraction of Cell Lines Where Essential: 10/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	2/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4277
Expression level (log2 read counts): 6.43

Expression Distribution

zf-CCHC
RRM 1

pre-mRNA intronic pyrimidine-rich binding
IRES-dependent translational initiation of linear mRNA
cap-independent translational initiation
cap-independent translational initiation of linear mRNA
circadian regulation of translation
negative regulation of translation in response to stress
pre-mRNA intronic binding
miRNA mediated inhibition of translation
negative regulation of translation, ncRNA-mediated
regulation of translation, ncRNA-mediated
regulation of translation in response to stress
negative regulation of translational initiation
entrainment of circadian clock by photoperiod
photoperiodism
entrainment of circadian clock
cytoplasmic translational initiation
cyclin binding
miRNA binding
response to arsenic-containing substance
mRNA cis splicing, via spliceosome
gene silencing by miRNA
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
regulation of alternative mRNA splicing, via spliceosome
cytoplasmic stress granule
cytoplasmic translation
mRNA 3-UTR binding
regulation of translational initiation
positive regulation of muscle cell differentiation
gene silencing by RNA
regulation of mRNA splicing, via spliceosome
regulation of nucleocytoplasmic transport
regulation of circadian rhythm
negative regulation of translation
regulation of RNA splicing
regulation of mRNA processing
circadian rhythm
translational initiation
negative regulation of cellular amide metabolic process
gene silencing