RETSAT

Entrez Summary: N/A
UniProt Summary: Catalyzes the saturation of all-trans-retinol to all- trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. {ECO:0000250|UniProtKB:Q64FW2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Quercetin 20μM R08 exp517	-2.68
Golgicide-A 4μM R03 exp122	1.95
Actinomycin-D 0.01μM R00 exp4	2.16
Epigallocatechin gallate 20μM R05 exp230	2.39

all-trans-retinol 13,14-reductase activity
nuclear outer membrane
retinol metabolic process
primary alcohol metabolic process
retinoid metabolic process
diterpenoid metabolic process
oxidoreductase activity
terpenoid metabolic process
cellular hormone metabolic process
isoprenoid metabolic process
hormone metabolic process
nuclear membrane
alcohol metabolic process
organic hydroxy compound metabolic process
regulation of hormone levels
endoplasmic reticulum membrane
cellular lipid metabolic process
oxidation-reduction process
lipid metabolic process
small molecule metabolic process
membrane