REV1

Entrez Summary: N/A
UniProt Summary: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dorsomorphin 5μM R07 exp357	-2.13
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-2.01
Mitomycin-C 0.06μM R08 exp503	-1.96
R-DABN 8μM R03 exp111	1.79
SB203580 25μM R03 exp149	1.86
Cincreasin 100μM R08 exp473	1.92

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

deoxycytidyl transferase activity
error-free translesion synthesis
error-prone translesion synthesis
DNA-directed DNA polymerase activity
translesion synthesis
DNA synthesis involved in DNA repair
postreplication repair
damaged DNA binding
DNA biosynthetic process
response to UV
DNA replication
response to light stimulus
response to radiation
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
nucleobase-containing compound biosynthetic process
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process