RGS8

Entrez Summary: N/A
UniProt Summary: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity). {ECO:0000250|UniProtKB:P49804, ECO:0000269|PubMed:18434541}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Artemisinin 50μM R08 exp450	-2.08
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.74
Lead acetate 2000μM R08 exp497	-1.73
RO-3306 3 to 4μM on day4 R04 exp165	1.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of dopamine receptor signaling pathway
G protein-coupled acetylcholine receptor signaling pathway
neuronal cell body membrane
acetylcholine receptor signaling pathway
response to acetylcholine
cellular response to acetylcholine
regulation of cellular response to drug
postsynaptic signal transduction
extrinsic component of cytoplasmic side of plasma membrane
signal transduction involved in cellular response to ammonium ion
regulation of response to drug
cellular response to ammonium ion
perikaryon
response to ammonium ion
GTPase activator activity
GTPase activity
cellular response to drug
positive regulation of GTPase activity
dendrite
synaptic signaling
regulation of GTPase activity
cellular response to hormone stimulus
cellular response to nitrogen compound
positive regulation of hydrolase activity
response to hormone
response to drug
cellular response to oxygen-containing compound
response to nitrogen compound
cell-cell signaling
cellular response to endogenous stimulus
negative regulation of signal transduction
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity
response to endogenous stimulus
response to oxygen-containing compound
negative regulation of response to stimulus
positive regulation of molecular function