RNF149

Gene Information

Official Symbol: RNF149
Official Name: ring finger protein 149
Aliases and Previous Symbols: N/A
Entrez ID: 284996
UniProt: Q8NC42
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. {ECO:0000269|PubMed:22628551}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04μM R07 exp418	-2.91
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.73
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.96
Aphidicolin 0.4μM R08 exp440	-1.7
Artemisinin 50μM R08 exp450	-1.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5062
Expression level (log2 read counts): 4.74

Expression Distribution

PA
zf-C3HC4
zf-rbx1

negative regulation of MAPK cascade
ubiquitin protein ligase activity
regulation of protein stability
cellular response to drug
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
proteolysis involved in cellular protein catabolic process
negative regulation of protein modification process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of MAPK cascade
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
response to drug
negative regulation of cellular protein metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
negative regulation of protein metabolic process
negative regulation of signal transduction
proteolysis
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
regulation of phosphorylation
negative regulation of response to stimulus
organic substance catabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
cellular catabolic process
regulation of intracellular signal transduction
regulation of protein modification process
membrane