RSPH3
Gene Information
- Official Symbol: RSPH3
- Official Name: radial spoke head 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 83861
- UniProt: Q86UC2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene acts as a protein kinase A anchoring protein. Mutations in this gene cause primary ciliary dyskinesia; a disorder characterized by defects of the axoneme in motile cilia and sperm flagella. The homolog of this gene was first identified in the blue-green algae Chlamydomonas as encoding a radial spoke protein that formed a structural component of motile cilia and flagella. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016].
- UniProt Summary: Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia. {ECO:0000269|PubMed:19684019}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14215
- Expression level (log2 read counts): 3.9
RSPH3 Expression in NALM6 Cells: 3.9
