SDC2

Entrez Summary: N/A
UniProt Summary: Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Thalidomide 20μM R07 exp406	-1.92
ETC-159 50μM R08 exp480	1.81

dendrite morphogenesis
glycosaminoglycan catabolic process
aminoglycan catabolic process
ephrin receptor signaling pathway
PDZ domain binding
regulation of dendrite morphogenesis
lysosomal lumen
Golgi lumen
dendrite development
retinoid metabolic process
glycosaminoglycan biosynthetic process
aminoglycan biosynthetic process
diterpenoid metabolic process
terpenoid metabolic process
isoprenoid metabolic process
regulation of dendrite development
glycosaminoglycan metabolic process
aminoglycan metabolic process
carbohydrate derivative catabolic process
endoplasmic reticulum lumen
regulation of cell morphogenesis involved in differentiation
post-translational protein modification
collagen-containing extracellular matrix
leukocyte migration
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
regulation of cell morphogenesis
regulation of neuron projection development
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
cell morphogenesis involved in differentiation
cell surface
carbohydrate derivative biosynthetic process
regulation of neuron differentiation
neuron projection development
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
enzyme linked receptor protein signaling pathway