SDCCAG8

Entrez Summary: This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010].
UniProt Summary: Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). May play a role in ciliogenesis. {ECO:0000250|UniProtKB:Q80UF4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PF-06409577 20μM R07 exp389	-1.87
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.78
Zebularine 20μM R07 exp423	-1.7
Cytochalasin-B 5μM R07 exp349	1.74
Epigallocatechin gallate 20μM R05 exp230	1.87
NFN1 0.1μM R01 exp49	2
Latrunculin-B 10μM R07 exp374	2.09
Tozasertib 0.1μM R07 exp414	2.38

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

photoreceptor cell cilium
centriolar satellite
regulation of cilium assembly
centrosome cycle
microtubule organizing center organization
ciliary basal body-plasma membrane docking
establishment of cell polarity
neuron migration
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
ciliary basal body
centriole
tube formation
organelle localization by membrane tethering
cell-cell junction
membrane docking
regulation of G2/M transition of mitotic cell cycle
establishment or maintenance of cell polarity
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of cell cycle G2/M phase transition
regulation of organelle assembly
mitotic cell cycle phase transition
cell cycle phase transition
cilium assembly
cilium organization
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition
cell projection assembly
microtubule cytoskeleton organization
centrosome
organelle localization
mitotic cell cycle process
regulation of mitotic cell cycle
tube morphogenesis
microtubule-based process
mitotic cell cycle
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization