SETD7

Entrez Summary: N/A
UniProt Summary: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. {ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:17108971}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 2μM R05 exp210	-2.07
GSK-J4 1μM R07 exp362	-1.87
GSK626616 14μM R08 exp485	-1.79
Epigallocatechin gallate 20μM R05 exp230	-1.71
Palbociclib 1μM R07 exp382	1.71
Calcium Ionophore 0.4μM R07 exp342	1.79
R-DABN 8μM R03 exp111	1.86
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.9

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptidyl-lysine monomethylation
peptidyl-lysine dimethylation
heterochromatin organization
histone-lysine N-methyltransferase activity
regulation of histone H3-K9 methylation
protein-lysine N-methyltransferase activity
regulation of histone methylation
p53 binding
histone lysine methylation
peptidyl-lysine methylation
histone methylation
chromosome
response to ethanol
protein methylation
protein alkylation
regulation of histone modification
regulation of chromatin organization
response to alcohol
macromolecule methylation
response to antibiotic
methylation
peptidyl-lysine modification
regulation of chromosome organization
histone modification
covalent chromatin modification
chromatin binding
response to toxic substance
chromatin organization
cellular response to DNA damage stimulus
nucleolus
peptidyl-amino acid modification
response to drug
chromosome organization
regulation of organelle organization
positive regulation of transcription, DNA-templated
response to oxygen-containing compound
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular response to stress
positive regulation of RNA metabolic process