SLC34A1
Gene Information
- Official Symbol: SLC34A1
- Official Name: solute carrier family 34 member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6569
- UniProt: Q06495
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
- UniProt Summary: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. {ECO:0000269|PubMed:26047794, ECO:0000269|PubMed:8327470}.
Pfam Domains GO Terms
Pfam Domains
| Na Pi cotrans |
GO Terms
| regulation of phosphate transmembrane transport |
| indole metabolic process |
| positive regulation of phosphate transmembrane transport |
| gentamycin metabolic process |
| arsenate ion transmembrane transport |
| positive regulation of sodium-dependent phosphate transport |
| positive regulation of inorganic anion transmembrane transport |
| cellular response to staurosporine |
| sodium-dependent phosphate transmembrane transporter activity |
| response to staurosporine |
| sodium-dependent phosphate transport |
| regulation of sodium-dependent phosphate transport |
| regulation of inorganic anion transmembrane transport |
| dentinogenesis |
| positive regulation of anion transmembrane transport |
| sodium:phosphate symporter activity |
| cellular phosphate ion homeostasis |
| cellular trivalent inorganic anion homeostasis |
| regulation of phosphate transport |
| cellular divalent inorganic anion homeostasis |
| cellular response to parathyroid hormone stimulus |
| aminoglycoside antibiotic metabolic process |
| response to mercury ion |
| trivalent inorganic anion homeostasis |
| cellular anion homeostasis |
| phosphate ion homeostasis |
| response to parathyroid hormone |
| cellular monovalent inorganic anion homeostasis |
| divalent inorganic anion homeostasis |
| tricarboxylic acid metabolic process |
| positive regulation of membrane potential |
| sodium ion import across plasma membrane |
| response to potassium ion |
| phosphate ion transmembrane transport |
| response to vitamin A |
| response to magnesium ion |
| glycoside metabolic process |
| phosphate ion transport |
| response to lead ion |
| indole-containing compound metabolic process |
| response to thyroid hormone |
| monovalent inorganic anion homeostasis |
| regulation of anion transmembrane transport |
| response to growth hormone |
| cellular response to alkaloid |
| positive regulation of anion transport |
| brush border |
| brush border membrane |
| anion homeostasis |
| response to cadmium ion |
| inorganic cation import across plasma membrane |
| inorganic ion import across plasma membrane |
| mitotic spindle |
| odontogenesis of dentin-containing tooth |
| response to vitamin |
| PDZ domain binding |
| sodium ion transmembrane transport |
| regulation of anion transport |
| import across plasma membrane |
| antibiotic metabolic process |
| inorganic anion transmembrane transport |
| polyol metabolic process |
| response to alkaloid |
| odontogenesis |
| cellular response to ammonium ion |
| glycosyl compound metabolic process |
| response to estradiol |
| vesicle |
| sodium ion transport |
| positive regulation of ion transmembrane transport |
| inorganic anion transport |
| response to ammonium ion |
| cellular response to metal ion |
| positive regulation of transmembrane transport |
| response to nutrient |
| cellular response to inorganic substance |
| membrane raft |
| ossification |
| protein-containing complex binding |
| kidney development |
| endosome |
| positive regulation of ion transport |
| anion transmembrane transport |
| renal system development |
| alcohol metabolic process |
| apical plasma membrane |
| urogenital system development |
| protein homooligomerization |
| response to metal ion |
| glycoprotein metabolic process |
| response to peptide hormone |
| monovalent inorganic cation transport |
| nuclear speck |
| regulation of membrane potential |
| organic hydroxy compound metabolic process |
| response to peptide |
| regulation of ion transmembrane transport |
| response to nutrient levels |
| drug metabolic process |
| protein complex oligomerization |
| response to extracellular stimulus |
| response to inorganic substance |
| cellular response to organic cyclic compound |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| anion transport |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cation transmembrane transport |
| cell surface |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| cellular response to nitrogen compound |
| import into cell |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| response to lipid |
| protein homodimerization activity |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| carboxylic acid metabolic process |
| response to hormone |
| response to organic cyclic compound |
| ion transmembrane transport |
| animal organ morphogenesis |
| positive regulation of transport |
| response to organonitrogen compound |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| response to nitrogen compound |
| chemical homeostasis |
| cellular response to endogenous stimulus |
| transmembrane transport |
| ion transport |
| integral component of plasma membrane |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| homeostatic process |
| small molecule metabolic process |
| protein-containing complex subunit organization |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Parthenolide 2.5μM R05 exp238 | -2.03 |
| BI-D1870 2μM R04 exp162 | -1.71 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.419 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12685
- Expression level (log2 read counts): -5.6
Expression Distribution
SLC34A1 Expression in NALM6 Cells: -5.6
