SLC6A11

Entrez Summary: N/A
UniProt Summary: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.7
Docetaxel 0.002μM R01 exp45	2.19
Taxol 0.002μM R01 exp54	2.33

gamma-aminobutyric acid:sodium symporter activity
neurotransmitter binding
gamma-aminobutyric acid transport
neurotransmitter reuptake
neurotransmitter uptake
integral component of postsynaptic membrane
integral component of presynaptic membrane
GABA-ergic synapse
amino acid transport
monocarboxylic acid transport
neurotransmitter transport
organic acid transport
carboxylic acid transport
neuron projection
regulation of neurotransmitter levels
organic anion transport
anion transport
import into cell
brain development
head development
central nervous system development
response to drug
transmembrane transport
ion transport
establishment of localization in cell
nitrogen compound transport