SLFN14

Entrez Summary: The protein encoded by this gene plays an important role in platelet formation and function. Defects in this gene are a cause of thrombocytopenia with excessive bleeding. [provided by RefSeq, Jul 2016].
UniProt Summary: Protein SLFN14: Shows no ribosome-associated and endoribonuclease activities. {ECO:0000269|PubMed:25996083}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

platelet maturation
cellular response to magnesium ion
cellular response to manganese ion
rRNA catabolic process
response to manganese ion
response to magnesium ion
endoribonuclease activity
ncRNA catabolic process
ribosome binding
RNA phosphodiester bond hydrolysis, endonucleolytic
anatomical structure maturation
cell maturation
RNA phosphodiester bond hydrolysis
cellular response to metal ion
mRNA catabolic process
cellular response to inorganic substance
rRNA metabolic process
developmental maturation
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
response to metal ion
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ncRNA metabolic process
organic cyclic compound catabolic process
response to inorganic substance
mRNA metabolic process
cellular macromolecule catabolic process
macromolecule catabolic process
ATP binding
cell development
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process