SLIT1

Entrez Summary: N/A
UniProt Summary: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dorsal/ventral axon guidance
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
embryonic olfactory bulb interneuron precursor migration
negative regulation of synapse assembly
tangential migration from the subventricular zone to the olfactory bulb
axon extension involved in axon guidance
neuron projection extension involved in neuron projection guidance
Roundabout binding
olfactory bulb interneuron development
forebrain morphogenesis
substrate-independent telencephalic tangential migration
substrate-independent telencephalic tangential interneuron migration
olfactory bulb interneuron differentiation
retinal ganglion cell axon guidance
nuclear migration
negative regulation of synapse organization
nucleus localization
motor neuron axon guidance
forebrain neuron development
olfactory bulb development
olfactory lobe development
brain morphogenesis
axon extension
negative chemotaxis
forebrain neuron differentiation
telencephalon cell migration
neuron projection extension
forebrain cell migration
forebrain generation of neurons
central nervous system neuron development
cell
developmental cell growth
cell growth
regulation of synapse assembly
developmental growth involved in morphogenesis
heparin binding
central nervous system neuron differentiation
regulation of synapse organization
regulation of synapse structure or activity
telencephalon development