SLIT2

Gene Information

Official Symbol: SLIT2
Official Name: slit guidance ligand 2
Aliases and Previous Symbols: N/A
Entrez ID: 9353
UniProt: O94813
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11379
Expression level (log2 read counts): -2.84

Expression Distribution

Screen	Score
SB202190 10μM R03 exp148	-1.92
Hydroxyurea 100μM R07 exp329	1.91

EGF
Laminin G 2
LRRNT
Laminin G 1
LRR 4

corticospinal neuron axon guidance through spinal cord
induction of negative chemotaxis
positive regulation of negative chemotaxis
negative regulation of retinal ganglion cell axon guidance
postnatal olfactory bulb interneuron migration
negative regulation of neutrophil chemotaxis
negative regulation of granulocyte chemotaxis
corticospinal neuron axon guidance
cerebral cortex tangential migration using cell-cell interactions
chemorepulsion involved in postnatal olfactory bulb interneuron migration
negative regulation of neutrophil migration
apoptotic process involved in luteolysis
negative regulation of lamellipodium assembly
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
embryonic olfactory bulb interneuron precursor migration
regulation of negative chemotaxis
negative regulation of smooth muscle cell chemotaxis
negative regulation of lamellipodium organization
substrate-dependent cerebral cortex tangential migration
regulation of retinal ganglion cell axon guidance
Roundabout signaling pathway
cellular response to heparin
response to cortisol
laminin-1 binding
negative regulation of monocyte chemotaxis
response to heparin
luteolysis
regulation of smooth muscle cell chemotaxis
corticospinal tract morphogenesis
negative regulation of chemokine-mediated signaling pathway
tangential migration from the subventricular zone to the olfactory bulb
Roundabout binding
response to anticoagulant
axon extension involved in axon guidance
negative regulation of mononuclear cell migration
neuron projection extension involved in neuron projection guidance
cerebral cortex tangential migration
olfactory bulb interneuron development
regulation of chemokine-mediated signaling pathway
negative regulation of vascular permeability