SNAPC3

Entrez Summary: N/A
UniProt Summary: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 674/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	24/28
bone	26/26
breast	29/33
central nervous system	54/56
cervix	4/4
colorectal	15/17
esophagus	12/13
fibroblast	1/1
gastric	15/16
kidney	18/21
liver	17/20
lung	68/75
lymphocyte	14/16
ovary	26/26
pancreas	24/24
peripheral nervous system	12/16
plasma cell	14/15
prostate	0/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	26/29
uterus	5/5

Expression Distribution

transcription by RNA polymerase III
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
nuclear body
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleolus
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression