SNCB

Entrez Summary: This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
UniProt Summary: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cuprous ion binding
phospholipase inhibitor activity
transition metal ion binding
inclusion body
dopamine metabolic process
presynaptic endocytosis
synaptic vesicle endocytosis
catecholamine metabolic process
catechol-containing compound metabolic process
synaptic vesicle recycling
phenol-containing compound metabolic process
presynapse
synaptic vesicle cycle
vesicle-mediated transport in synapse
negative regulation of neuron apoptotic process
ammonium ion metabolic process
negative regulation of neuron death
regulation of neuron apoptotic process
synapse organization
regulation of neuron death
response to metal ion
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
organic hydroxy compound metabolic process
synaptic signaling
drug metabolic process
response to inorganic substance
endocytosis
import into cell
calcium ion binding
negative regulation of catalytic activity
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
cell-cell signaling
negative regulation of molecular function
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death