SND1

Entrez Summary: This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016].
UniProt Summary: Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	1.81
Aminopterin 0.005μM R07 exp335	1.87
Vincristine 0.0005μM R04 exp190	1.89
Tubacin 1.6μM R07 exp416	1.93
UM0125461 0.74μM R02 exp84	2.3

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SNase
TUDOR

RISC complex binding
dense body
miRNA catabolic process
nuclease activity
RISC complex
miRNA metabolic process
endoribonuclease activity
ncRNA catabolic process
endonuclease activity
RNA phosphodiester bond hydrolysis, endonucleolytic
transcription coregulator activity
gene silencing by RNA
melanosome
osteoblast differentiation
gene silencing
RNA phosphodiester bond hydrolysis
RNA catabolic process
ossification
nucleic acid phosphodiester bond hydrolysis
cadherin binding
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ncRNA metabolic process
organic cyclic compound catabolic process
viral process
regulation of cell cycle process
symbiotic process
interspecies interaction between organisms
cellular macromolecule catabolic process
macromolecule catabolic process
regulation of cell cycle
RNA binding
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process
membrane