SNX18

Entrez Summary: N/A
UniProt Summary: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cleavage furrow formation
cytokinetic process
clathrin-coated vesicle
extrinsic component of cytoplasmic side of plasma membrane
mitotic cytokinesis
phosphatidylinositol-4,5-bisphosphate binding
cytoskeleton-dependent cytokinesis
cytokinesis
plasma membrane invagination
cytoplasmic vesicle membrane
membrane invagination
endosome membrane
endosomal transport
cytoplasmic vesicle
positive regulation of GTPase activity
regulation of GTPase activity
cell division
endocytosis
mitotic cell cycle process
import into cell
mitotic cell cycle
positive regulation of hydrolase activity
membrane organization
cell cycle process
regulation of hydrolase activity
cell cycle
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport