STAM2

Entrez Summary: N/A
UniProt Summary: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ESCRT-0 complex
multivesicular body assembly
multivesicular body organization
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of ERBB signaling pathway
endosome organization
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
early endosome membrane
macroautophagy
endosomal transport
autophagy
process utilizing autophagic mechanism
protein deubiquitination
protein modification by small protein removal
vesicle organization
endomembrane system organization
intracellular membrane-bounded organelle
organelle assembly
membrane organization
protein modification by small protein conjugation or removal
intracellular protein transport
negative regulation of signal transduction
proteolysis
negative regulation of cell communication
negative regulation of signaling
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
negative regulation of response to stimulus
cellular catabolic process
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport