STAMBP

Entrez Summary: Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250, ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.87
UM131593 0.2μM R03 exp106	-1.85
CVT-10216 0.1μM R06 exp278	-1.75
HMS-I1 1μM R01 exp46	-1.74
DABN 20μM R00 exp17	1.77
ZLN024 50μM R08 exp538	1.84

Global Fraction of Cell Lines Where Essential: 71/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	2/26
breast	2/33
central nervous system	2/56
cervix	1/4
colorectal	1/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	8/21
liver	0/20
lung	8/75
lymphocyte	0/16
ovary	2/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	9/22
urinary tract	2/29
uterus	0/5

Expression Distribution

Lys63-specific deubiquitinase activity
negative regulation of phosphatidylinositol 3-kinase signaling
protein K63-linked deubiquitination
receptor signaling pathway via JAK-STAT
receptor signaling pathway via STAT
negative regulation of Ras protein signal transduction
cleavage furrow
negative regulation of small GTPase mediated signal transduction
metallopeptidase activity
mitotic cytokinesis
cytoskeleton-dependent cytokinesis
cytokinesis
thiol-dependent ubiquitin-specific protease activity
regulation of phosphatidylinositol 3-kinase signaling
negative regulation of neuron apoptotic process
regulation of neuron apoptotic process
negative regulation of neuron death
regulation of Ras protein signal transduction
protein domain specific binding
early endosome
endosome
protein deubiquitination
protein modification by small protein removal
regulation of neuron death
regulation of small GTPase mediated signal transduction
cell division
negative regulation of intracellular signal transduction
mitotic cell cycle process
mitotic cell cycle
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of cell population proliferation
protein modification by small protein conjugation or removal
negative regulation of cell death
cell cycle process
negative regulation of signal transduction
proteolysis
cell cycle
negative regulation of cell communication
negative regulation of signaling