STON2

Entrez Summary: N/A
UniProt Summary: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UNC1999 2μM R03 exp155	1.7
Prochlorperazine 5.2μM R02 exp77	1.74
CCCP 1μM R00 exp11	1.8
Lapatinib 5μM R01 exp47	1.87
Ribavirin 10μM R01 exp52	2.02
HMS-I1 1μM R01 exp46	2.16
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.43

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Stonin2 N
Adap comp sub

synaptic vesicle endocytosis
presynaptic endocytosis
synaptic vesicle recycling
clathrin-coated vesicle
hematopoietic progenitor cell differentiation
synaptic vesicle cycle
synaptic vesicle
vesicle-mediated transport in synapse
regulation of endocytosis
neuron projection
cell junction
regulation of vesicle-mediated transport
endocytosis
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
import into cell
membrane organization
nucleolus
establishment of localization in cell
regulation of transport
vesicle-mediated transport
membrane