STX8

Entrez Summary: The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-2.14
Nocodazole 0.2μM R00 exp24	-1.8
TIC10 10μM R08 exp532	-1.72
BML-284 0.09μM R08 exp460	1.75
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.78
Rapamycin 2μM R07 exp306	1.84
Dexamethasone 0.006μM R07 exp351	1.87
Vemurafenib 6.6μM R08 exp434	1.87
Zebularine 20μM R07 exp423	1.93
LY2090314 0.003μM R08 exp500 no dilution day6	2
GSK2606414 1μM R05 exp236	2.04

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chloride channel inhibitor activity
early endosome to late endosome transport
vesicle-mediated transport between endosomal compartments
SNAP receptor activity
SNARE complex
endosome to lysosome transport
syntaxin binding
phagocytic vesicle
vesicle docking
SNARE binding
vesicle fusion
endomembrane system
organelle membrane fusion
regulation of protein localization to plasma membrane
organelle fusion
lysosomal transport
regulation of protein localization to cell periphery
recycling endosome
late endosome membrane
late endosome
membrane fusion
vacuolar transport
vesicle
cytosolic transport
cellular response to interferon-gamma
organelle localization by membrane tethering
trans-Golgi network
membrane docking
response to interferon-gamma
regulation of protein localization to membrane
early endosome
endosome
ubiquitin protein ligase binding
lysosomal membrane
vesicle organization
regulation of cellular protein localization
organelle localization
perinuclear region of cytoplasm
innate immune response
membrane organization