SUCO

Entrez Summary: N/A
UniProt Summary: Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

rough endoplasmic reticulum membrane
protein folding in endoplasmic reticulum
positive regulation of collagen biosynthetic process
positive regulation of collagen metabolic process
regulation of collagen biosynthetic process
regulation of collagen metabolic process
regulation of bone remodeling
positive regulation of osteoblast differentiation
rough endoplasmic reticulum
regulation of tissue remodeling
positive regulation of ossification
regulation of osteoblast differentiation
regulation of ossification
protein folding
ossification
positive regulation of cell differentiation
positive regulation of developmental process
positive regulation of multicellular organismal process
regulation of cell differentiation
membrane
positive regulation of biosynthetic process