SUN1
Gene Information
- Official Symbol: SUN1
- Official Name: Sad1 and UNC84 domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 23353
- UniProt: O94901
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Sad1 UNC |
| MRP |
GO Terms
| nuclear matrix anchoring at nuclear membrane |
| nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration |
| nuclear matrix organization |
| modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration |
| meiotic attachment of telomere to nuclear envelope |
| chromosome attachment to the nuclear envelope |
| meiotic telomere tethering at nuclear periphery |
| telomere tethering at nuclear periphery |
| nuclear migration along microtubule |
| cell motility involved in cerebral cortex radial glia guided migration |
| cytoskeletal anchoring at nuclear membrane |
| meiotic nuclear membrane microtubule tethering complex |
| meiotic telomere clustering |
| chromosome localization to nuclear envelope involved in homologous chromosome segregation |
| telomere localization |
| protein membrane anchor |
| integral component of nuclear inner membrane |
| lamin binding |
| maintenance of protein location in nucleus |
| cerebral cortex radial glia guided migration |
| telencephalon glial cell migration |
| nuclear migration |
| nucleus localization |
| centrosome localization |
| cerebral cortex radially oriented cell migration |
| microtubule organizing center localization |
| glial cell migration |
| maintenance of protein localization in organelle |
| cerebral cortex cell migration |
| synapsis |
| nuclear envelope organization |
| homologous chromosome segregation |
| telencephalon cell migration |
| forebrain cell migration |
| chromosome organization involved in meiotic cell cycle |
| establishment of chromosome localization |
| chromosome localization |
| maintenance of protein location in cell |
| organelle transport along microtubule |
| meiotic chromosome segregation |
| maintenance of location in cell |
| maintenance of protein location |
| meiosis I |
| meiosis I cell cycle process |
| cerebral cortex development |
| nucleus organization |
| meiotic nuclear division |
| transport along microtubule |
| protein localization to nucleus |
| maintenance of location |
| meiotic cell cycle process |
| pallium development |
| cytoskeleton-dependent intracellular transport |
| nuclear envelope |
| microtubule-based transport |
| response to mechanical stimulus |
| gliogenesis |
| nuclear chromosome segregation |
| meiotic cell cycle |
| nuclear membrane |
| telencephalon development |
| ossification |
| microtubule-based movement |
| chromosome segregation |
| nuclear division |
| organelle fission |
| establishment of organelle localization |
| forebrain development |
| endomembrane system organization |
| microtubule cytoskeleton organization |
| spermatogenesis |
| male gamete generation |
| organelle localization |
| microtubule-based process |
| intracellular membrane-bounded organelle |
| gamete generation |
| protein localization to organelle |
| brain development |
| head development |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| membrane organization |
| cell migration |
| central nervous system development |
| multi-organism reproductive process |
| cell cycle process |
| chromosome organization |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| response to abiotic stimulus |
| locomotion |
| cell cycle |
| reproductive process |
| reproduction |
| intracellular transport |
| movement of cell or subcellular component |
| cellular protein localization |
| cellular macromolecule localization |
| neurogenesis |
| establishment of localization in cell |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Thioridazine 5μM R08 exp530 | 1.74 |
| Nocodazole 0.2μM R00 exp24 | 1.83 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16144
- Expression level (log2 read counts): 7.29
Expression Distribution
SUN1 Expression in NALM6 Cells: 7.29
