TADA2A

Entrez Summary: N/A
UniProt Summary: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pyridostatin 4μM R05 exp240	1.71
Sulforaphane 9μM R08 exp526 no dilution day6	1.71
Brefeldin A 0.02μM R00 exp8	1.74
Ammonium tetrathiomolybdate 10μM R08 exp448	1.76
Centrinone 0.5μM R07 exp343	1.8
ML-792 0.2μM R08 exp505	1.89
Genistein 15μM R07 exp360	1.92
Olaparib 4μM R08 exp512	1.95
Deferoxamine 11μM R07 exp350	2.05
MLN-4924 0.2μM R00 exp21	2.07
Deguelin 0.15μM R05 exp209	2.17
QNZ 0.01μM R05 exp241	2.28
AICAR 240μM R05 exp211	2.33
Bortezomib 0.005μM R00 exp6	2.43
UM0131023 0.05μM R05 exp248	2.51
MS023 7μM R03 exp135	3.16
THZ531 0.225μM R08 exp444	3.47
MS023 2μM R03 exp134	3.53
Actinomycin-D 0.001μM R00 exp3	3.65

Global Fraction of Cell Lines Where Essential: 13/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/25
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Myb DNA-binding
SWIRM

PCAF complex
SAGA-type complex
positive regulation of histone acetylation
positive regulation of peptidyl-lysine acetylation
positive regulation of protein acetylation
histone H3 acetylation
histone acetyltransferase activity
regulation of histone acetylation
regulation of peptidyl-lysine acetylation
regulation of protein acetylation
positive regulation of histone modification
positive regulation of chromatin organization
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
chromosome
protein acetylation
regulation of histone modification
chromatin remodeling
positive regulation of chromosome organization
protein acylation
regulation of chromatin organization
transcription coactivator activity
peptidyl-lysine modification
regulation of chromosome organization
histone modification
covalent chromatin modification
chromatin binding
positive regulation of organelle organization
chromatin organization
peptidyl-amino acid modification
chromosome organization
positive regulation of cellular component organization
positive regulation of protein modification process
regulation of organelle organization
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of cellular protein metabolic process
positive regulation of nucleic acid-templated transcription