TAF1B

Official Symbol: TAF1B
Official Name: TATA-box binding protein associated factor, RNA polymerase I subunit B
Aliases and Previous Symbols: N/A
Entrez ID: 9014
UniProt: Q53T94
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:21921198, ECO:0000269|PubMed:21921199, ECO:0000269|PubMed:7491500, ECO:0000269|PubMed:7801123, ECO:0000269|PubMed:7801130}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 62/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	3/25
breast	3/33
central nervous system	6/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	1/15
kidney	4/21
liver	1/20
lung	5/75
lymphocyte	2/14
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	3/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	5/29
uterus	0/5

Expression Distribution

Screen	Score
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.08
L-74142 5μM R03 exp131	-1.73
Cannabidiol 20μM R08 exp466	2.12

RNA polymerase I core factor complex
RNA polymerase transcription factor SL1 complex
nucleolar large rRNA transcription by RNA polymerase I
RNA polymerase I CORE element sequence-specific DNA binding
RNA polymerase I preinitiation complex assembly
rRNA transcription
TBP-class protein binding
transcription elongation from RNA polymerase I promoter
transcription preinitiation complex assembly
termination of RNA polymerase I transcription
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of gene expression, epigenetic
DNA-templated transcription, termination
DNA-templated transcription, elongation
ncRNA transcription
protein-DNA complex assembly
DNA-templated transcription, initiation
regulation of gene expression, epigenetic
protein-DNA complex subunit organization
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cellular protein-containing complex assembly
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
positive regulation of gene expression
gene expression