TAF4

Entrez Summary: N/A
UniProt Summary: Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	2/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TAF4
TAFH

aryl hydrocarbon receptor binding
transcription factor TFTC complex
MLL1 complex
transcription factor TFIID complex
ovarian follicle development
female gonad development
development of primary female sexual characteristics
female sex differentiation
transcription initiation from RNA polymerase II promoter
regulation of signal transduction by p53 class mediator
gonad development
development of primary sexual characteristics
DNA-templated transcription, initiation
nuclear chromatin
sex differentiation
transcription coactivator activity
transcription factor binding
reproductive structure development
reproductive system development
transcription by RNA polymerase II
protein heterodimerization activity
protein-containing complex
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
developmental process involved in reproduction
DNA-binding transcription factor activity
viral process
symbiotic process
interspecies interaction between organisms
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
reproductive process
reproduction
DNA binding
positive regulation of transcription, DNA-templated
cellular nitrogen compound biosynthetic process